Synthesis and antifungal activities of alanine-exchanged analogs of pradimicin A.
نویسندگان
چکیده
A series of pradimicin analogs were designed and synthesized to investigate the effect of the amino acid side chain on the antifungal activity. The alanine-exchanged analogs (3a approximately 3q) were synthesized from 4'-N-Cbz-pradimic acid by coupling with appropriate amino acids or their equivalents followed by deblocking. All the D-alpha-amino acid derivatives except D-proline analog, 3k retained the antifungal activity.
منابع مشابه
Synthesis and antifungal activities of pradimicin A derivatives modification of the alanine moiety.
Chemical modifications of the carboxyl group in the alanine moiety of pradimicin A were performed and in vitro and in vivo antifungal activities of the derivatives were examined in comparison with those of pradimicin A. The amide derivatives showed activities comparable to pradimicin A, indicating that the free carboxyl group can be modified without impairing the antifungal activity.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 46 3 شماره
صفحات -
تاریخ انتشار 1993